DVT and PE

Deep vein thrombosis (DVT) is a blood clot in the deep veins of the leg, causing swelling and pain. If it is not treated, part of the clot can travel to the lungs and cause a pulmonary embolism, which can be fatal. Early diagnosis and the right treatment prevent these complications.

DVT and PE

Medically reviewed by Dr. Aniruddha Bhuiyan, MCh vascular surgeon. Updated October 2026.

Understanding deep vein thrombosis, superficial venous thrombosis and pulmonary embolism

Blood clots in the veins can be dangerous, especially a DVT, which forms deep inside the body and can go unnoticed. Some clots cause only mild symptoms. Others lead to permanent vein damage, ulcers that will not heal, or a life-threatening pulmonary embolism.

What is deep vein thrombosis (DVT)?

Deep vein thrombosis (DVT) is a blood clot in one of the deep veins of the body, most often in the legs or pelvis. These veins carry used blood back to the heart. When a clot blocks a deep vein, blood cannot flow back properly, and the limb becomes painful, swollen and heavy. The NHS also explains DVT symptoms and treatment in plain language.

Without treatment, the clot can break free and travel through the bloodstream to the lungs. This is a pulmonary embolism, and it is a medical emergency.

Deep Vein Thrombosis

What causes DVT?

DVT usually happens when three factors come together. Doctors call them Virchow’s triad:

  • Stasis (slow blood flow)
  • Endothelial injury (damage to the blood vessel lining)
  • Hypercoagulability (increased clotting tendency)

Common triggers include:

Risk factors for DVT

  • Age: the risk rises with age, especially over 60.
  • Smoking: affects how blood clots and damages vessel walls.
  • Genetics: inherited clotting disorders, such as Factor V Leiden or protein C or S deficiency.
  • Pregnancy: adds pressure on the pelvic veins and changes how the blood clots.
  • Hormones: oral contraceptives or hormone replacement therapy.
  • Obesity: extra weight raises pressure in the leg veins.
  • Long periods without moving: long flights, bed rest, recovery after surgery.
  • Cancer: some cancers make the blood clot more easily.
  • Idiopathic: sometimes doctors find no clear cause.

Symptoms of DVT

DVT can be silent. Common signs are:

  • Swelling in one leg (rarely both)
  • Pain or tenderness, especially in the calf or thigh
  • Warmth over the affected area
  • Red or discolored skin
  • Heaviness or fatigue in the limb

Other conditions can cause the same symptoms, so see a doctor promptly.

Pulmonary Embolism (PE)

What is pulmonary embolism (PE)?

A pulmonary embolism happens when a piece of a DVT clot breaks off, travels to the lungs and blocks their blood supply.

It is a life-threatening emergency.

Symptoms of pulmonary embolism

  • Sudden shortness of breath
  • Sharp chest pain, especially while breathing in
  • Rapid heart rate
  • Coughing (sometimes with blood)
  • Feeling lightheaded or fainting

A large PE can cause sudden collapse or death without immediate treatment.

Superficial venous thrombosis (SVT)

DVT affects the deep veins. Superficial venous thrombosis (SVT) affects veins close to the skin, usually visible, tender varicose veins.

SVT causes pain, redness and swelling along a vein under the skin. It is less dangerous than DVT, but it can spread into the deep veins, especially where the two systems join, so do not ignore it.

Differences between SVT and DVT

FeatureSVTDVT
LocationJust under the skinDeep within the limb
Risk of PELow, but possibleHigh
SymptomsRedness, cord-like veinSwelling, deep pain
TreatmentAnti-inflammatory, sometimes anticoagulantsAnticoagulants, imaging, intervention

Complications of untreated DVT

  • Pulmonary embolism: can be fatal
  • Post-thrombotic syndrome (PTS): long-term leg swelling, skin changes and ulcers
  • Recurrent DVT
  • Chronic venous insufficiency: damaged valves let blood flow backwards, causing discoloration and ulcers that do not heal

Postphlebitic syndrome

A DVT can damage the valves in the veins. Blood then leaks backwards down the leg (venous reflux), which leads to:

  • Persistent leg swelling
  • Skin pigmentation around the ankle
  • Hardening of the skin (lipodermatosclerosis)
  • Ulcers that are hard to heal
  • Bleeding from varicose or incompetent veins

This is why a DVT needs early diagnosis and proper treatment.

Diagnosis of DVT and PE

  • Venous Doppler ultrasound: the first test for DVT
  • D-dimer blood test: raised levels suggest clotting, but the test is not specific
  • CT pulmonary angiogram: the gold standard for detecting PE
  • MRI/MRV: for clots in the pelvic veins or other hard-to-see areas
  • Venography: rarely used now, but still helpful in some cases

Treatment options for DVT and PE

Treatment depends on where the clot is, how large it is, how long it has been there and whether there are complications. The aims are to:

  • Stop the clot from growing
  • Lower the risk of PE
  • Protect the veins
  • Prevent another clot
  • The first-line treatment
  • Stops new clots from forming and lets the body break down the existing clot
  • Includes heparin, low molecular weight heparin (LMWH) and direct oral anticoagulants (DOACs) such as apixaban and rivaroxaban
  • Duration: 3 to 6 months, or lifelong, depending on the cause
  • For large, fresh clots with a high risk of PE
  • The doctor delivers a clot-dissolving drug (such as alteplase) directly into the clot
  • Given through a catheter placed in the vein (catheter-directed thrombolysis)
  • The doctor removes the clot with special devices or suction
  • Used for large clots causing severe symptoms
  • Used when veins stay narrowed or blocked over the long term
  • Helps the vein drain properly in the long term
  • Especially useful for DVT in the pelvic veins (May-Thurner syndrome)
  • A filter placed in the inferior vena cava (IVC) stops clots from reaching the lungs
  • Used only in selected high-risk patients, or when blood thinners cannot be given
Venogram of a blocked left iliac vein after deep vein thrombosis, after angioplasty and after stenting

Treatment of superficial thrombophlebitis (SVT)

  • Anti-inflammatory painkillers (NSAIDs)
  • Compression stockings
  • Warm compresses
  • Blood thinners in some cases, especially if the clot is long or close to where it joins a deep vein

Preventing DVT

  • Moving regularly during long flights or after surgery
  • Compression stockings for high-risk patients
  • Drinking enough water
  • Weight control
  • Avoiding long periods of bed rest or sitting
  • Preventive blood thinners during surgery, after injury or during a hospital stay
  • Physiotherapy to keep the blood moving
  • Getting up and moving early after childbirth or bone and joint surgery

When to see a vascular surgeon

See a vascular specialist if you:

  • Have leg pain or swelling without an injury
  • Have a history of DVT or PE
  • Have visible veins that are tender or red
  • Are planning major surgery and have clotting risk factors
  • Need an expert opinion on DVT complications, such as non-healing ulcers or long-term swelling

Treating DVT early prevents long-term complications.

Frequently asked questions

How do I know if my leg swelling is a DVT?

Swelling in one leg with pain, warmth or redness, especially after a long journey, surgery or bed rest, should be checked with a venous Doppler ultrasound. The scan is painless and shows whether there is a clot.

Is a DVT an emergency?

It needs prompt treatment, because part of the clot can travel to the lungs. Sudden breathlessness, chest pain or coughing up blood can mean a pulmonary embolism and need emergency care.

How long will I need blood thinners?

Usually 3 to 6 months. Some patients need longer or lifelong treatment, depending on what caused the clot and the risk of another.

Can a DVT cause problems later?

Yes. Damage to the vein valves can cause post-thrombotic syndrome, with lasting swelling, darkening of the skin and ulcers near the ankle. Early treatment lowers this risk.

What is the difference between DVT and PE?

A DVT is a blood clot in a deep vein, usually in the leg. A PE (pulmonary embolism) happens when part of that clot breaks off and travels to the lungs. A DVT causes leg swelling and pain; a PE causes sudden breathlessness, chest pain or coughing up blood, and is an emergency.

We aim to detect venous disease early.

Your veins deserve attention

Many people ignore leg pain or swelling until it becomes serious. DVT and PE can be prevented, and they can be treated well when caught early. We aim to find vein disease early, treat it properly and follow patients over the long term so it does not come back. If you are at risk or have symptoms, book a consultation today.